ABSTRACT
Due to the global outbreak of COVID-19, the perishable product supply chains have been impacted in different ways, and consequently, the risks of food insecurity have been increased in many affected countries. The uncertainty in supply and demand of perishable products, are among the most influential factors impacting the supply chain networks. Accordingly, the provision and distribution of food and other perishable commodities have become much more important than in the past. In this study, a bi-objective optimization model is proposed for a three-echelon perishable food supply chain (PFSC) network with multiple products to formulate an integrated supplier selection, production scheduling, and vehicle routing problem. The proposed model aims to mitigate the risks of demand and supply uncertainties and reinforce the distribution-related decisions by simultaneously optimizing the total network costs and suppliers’ reliability. Using the distributionally robust modeling paradigm, the probability distribution of uncertain demand is assumed to belong to an ambiguity set with given moment information. Accordingly, distributionally robust chance-constrained approach is applied to ensure that the demands of retailers and capacity of vehicles are satisfied with high probability. Leveraging duality and linearization techniques, the proposed model is reformulated as a mixed-integer linear program. Then, the weighted goal programming approach is adopted to address the multi-objectiveness of the proposed optimization model. To certify the performance and applicability of the model, a real-world case study in the poultry industry is investigated. Finally, the sensitivity analysis is conducted to evaluate the impacts of influential parameters on the objective functions and optimal decisions, and then some managerial insights are provided based on the obtained results.
ABSTRACT
BACKGROUND AND AIMS: Acute respiratory distress syndrome (ARDS) or acute lung injury (ALI) is one of the most common acute thoracopathy with complicated pathogenesis in ICU. The study is to explore the differentially expressed genes (DEGs) in the lung tissue and underlying altering mechanisms in ARDS. METHODS: Gene expression profiles of GSE2411 and GSE130936 were available from GEO database, both of them included in GPL339. Then, an integrated analysis of these genes was performed, including gene ontology (GO) and KEGG pathway enrichment analysis in DAVID database, protein-protein interaction (PPI) network construction evaluated by the online database STRING, Transcription Factors (TFs) forecasting based on the Cytoscape plugin iRegulon, and their expression in varied organs in The Human Protein Atlas. RESULTS: A total of 39 differential expressed genes were screened from the two datasets, including 39 up-regulated genes and 0 down-regulated genes. The up-regulated genes were mainly enriched in the biological process, such as immune system process, innate immune response, inflammatory response, and also involved in some signal pathways, including cytokine-cytokine receptor interaction, Salmonella infection, Legionellosis, Chemokine, and Toll-like receptor signal pathway with an integrated analysis. GBP2, IFIT2 and IFIT3 were identified as hub genes in the lung by PPI network analysis with MCODE plug-in, as well as GO and KEGG re-enrichment. All of the three hub genes were regulated by the predictive common TFs, including STAT1, E2F1, IRF1, IRF2, and IRF9. CONCLUSIONS: This study implied that hub gene GBP2, IFIT2 and IFIT3, which might be regulated by STAT1, E2F1, IRF1, IRF2, or IRF9, played significant roles in ARDS. They could be potential diagnostic or therapeutic targets for ARDS patients.